A young man is held captive by a deranged surgeon and faced with the choice which can alter his life and the life of his loved ones forever.

Waldimar Daninsky, a lone survivor of a Tibetian expedition, returns home to find his wife has been unfaithful to him. Carrying the curse of the pentagram (or pentagon, as stated by the monk who nursed him back to health), the fury of the wolfman is unleashed! After disposing of his cheating spouse, he finds himself captive in a castle by a female mad scientist conducting mind control experiments. In a vein attempt at escape, he discovers the freaks left over from past experiments dwelling in the dungeons.

A scientist experimenting with suspended animation decides to use himself as a test subject. While he is frozen, his wife is murdered, and he becomes the primary suspect.